Pharmacological Therapy


The marketing clearance of Propecia is based on data from three one-year, double-blind, placebo-controlled, multicenter clinical trials involving 1,879 men aged 18 to 41 with mild to moderate hair loss of the vertex and anterior mid-scalp areas. In addition, 1,215 of the men who had hair loss at the vertex, or top of the head, were studied for another year.

Hair count increased during the first year and was maintained in those men taking Propecia for 24 months; men in the placebo group continued to show progressive hair loss. In an analysis of the men who were followed for up to two years, only 17 percent of men treated with Propecia demonstrated hair loss (defined as any decrease in hair count from baseline); 83 percent had the same or higher hair count. In contrast, 72 percent of the placebo group lost hair, as measured by hair count. Through questionnaires, all patients were asked to evaluate their response to treatment. Those on Propecia reported an increase in the amount of hair, a decrease in hair loss, and improvement in appearance. Clinical improvement was seen as early as three months.

In another analysis, a panel of independent dermatologists evaluated photos in 508 patients after 24 months of treatment. An increase in hair growth was demonstrated in 66 percent of men treated with Propecia compared to 7 percent of men treated with placebo. Efficacy in bitemporal recession has not been established. All men, whether receiving Propecia or placebo, were given a medicated shampoo (Neutrogena T/Gel Shampoo).

“Propecia works by inhibiting the conversion of testosterone to DHT (dihydro-testosterone),” said Keith Kaufman, M.D., senior director, Clinical Research, Merck Research Laboratories in Rahway, N.J. “It is the first treatment to target this key factor in the development of androgenetic alopecia in those patients genetically predisposed.”

Rogaine Extra Strength

Rogaine Extra Strength contains 5% Minoxidil, the only FDA approved topical treatment for hair loss. In clinical studies, four out of five users claimed Rogaine helped slow or stop their hair loss. Rogaine Extra Strength has 45% more regrowth than regular strength. This means that there is enhanced penetration of the hairs follicle and significantly more hair growth. Results may occur in as soon as 2 months.

Rogaine is a topical liquid, not a systemic medication. That means it’s applied to the top of your scalp, instead of taken internally. You’ll be relieved to know that Men’s Rogaine Extra Strength works without altering male hormones.

Rogaine is applied directly to the scalp in the hair loss area twice daily. For example, once in the morning and once at night. The night-time application should occur 2-4 hours before bed to allow for drying. Each bottle should last about 25-30 days if used as directed. Hair can be styled normally after the Rogaine has dried. The twinpack contains 2 month’s supply of Rogaine. A small percentage of users, about 6%, experience scalp irritation.